ZBTB46-AS1

Across TCGA pan-cancer cohorts, ZBTB46-AS1 RNA is linked to patient survival in 14 of 34 cancer types, making it the most broadly survival-associated ZBTB46-AS1 data layer.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher ZBTB46-AS1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated ZBTB46-AS1 expression acts as an unfavorable survival marker, although some lineages such as PAAD and SKCM show a favorable association.

COAD, LUSC, and PAAD are the cancer types where ZBTB46-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	OS	Tertile	All	0.584	0.831	.002	60	view →
LUSC	OS	Tertile	IV	0.001	0.673	.014	38	view →
PAAD	OS	Quartile	All	0.668	0.299	.002	37	view →
KIRC	DFS	Median	II,III,IV	0.421	0.618	.010	20	view →
UCEC	DFS	Median	II,III,IV	0.771	0.858	.019	20	view →
SKCM	DFS	Tertile	All	0.439	0.184	.009	9	view →
MESO	OS	Tertile	IV	0.423	0.622	.048	9	view →
HNSC	DFS	Tertile	All	0.444	0.289	.029	6	view →
OV	DFS	Tertile	II,III,IV	0.450	0.371	.034	4	view →
BLCA	DFS	Tertile	II,III,IV	0.559	0.644	.043	3	view →
THCA	OS	Median	All	1.000	0.985	.016	3	view →
ESCA	DFS	Median	All	0.927	0.545	.043	3	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 14 lineages.

ZBTB46-AS1–COAD (OS)

Open the COAD breakdown →