ZBTB45

Across TCGA pan-cancer cohorts, ZBTB45 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated ZBTB45 data layer compared with 24 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher ZBTB45 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated ZBTB45 expression acts as an unfavorable survival marker, although some lineages such as LSCC and CCRCC show a favorable association.

LSCC, UCEC, and CCRCC are the cancer types where ZBTB45 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Tertile	II,III,IV	0.954	0.639	.005	18	view →
UCEC	DFS	Tertile	All	0.789	1.000	.023	16	view →
CCRCC	DFS	Quartile	All	1.000	0.478	.043	1	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

ZBTB45–LSCC (DFS)

Open the LSCC breakdown →