Across TCGA pan-cancer cohorts, ZBTB44 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of ZBTB44’s most consistent transcriptional readouts.
The strongest signal is observed in kidney chromophobe (KICH), where ZBTB44 RNA is repressed in tumor relative to normal tissue. In most cancer types ZBTB44 is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.
KICH, THCA, and LIHC are the cancer types where ZBTB44 tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ZBTB44 RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.