ZBTB41

Across TCGA patient cohorts, ZBTB41 mutation is significantly associated with the total protein of many other genes, with 69 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZBTB41-associated genes across cancer lineages are EGFR_pY1068, ACC1, and Shc_pY317. Each is linked with ZBTB41 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZBTB41-to-partner and partner-to-ZBTB41 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by ZBTB41-low versus ZBTB41-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZBTB41→partner) and Y-score (partner→ZBTB41) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.271	-1.624	<.001	<.001	3	3
UCEC	ACC1 →	+0.332	+1.469	<.001	<.001	3	3
UCEC	Shc_pY317 →	-0.171	-2.201	<.001	<.001	3	3
UCEC	Caspase-7-cleavedD198 →	+0.548	+2.000	<.001	<.001	3	3
UCEC	4E-BP1 →	+0.335	+1.624	<.001	<.001	3	3
LUAD	PCNA →	+0.196	+2.820	.027	.035	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 69 associations by consensus.

EGFR_pY1068 by ZBTB41 expression — UCEC

Explore this box plot interactively →