Across TCGA pan-cancer cohorts, ZBTB40 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated ZBTB40 data layer compared with 25 for mass-spec protein and 3 for mass-spec protein.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher ZBTB40 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated ZBTB40 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

COAD, UCEC, and LGG are the cancer types where ZBTB40 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	IV	0.035	0.501	<.001	6	view →
UCEC	DFS	Median	All	0.737	0.634	.042	4	view →
LGG	OS	Median	All	0.306	0.799	.009	3	view →
SKCM	DFS	Median	III,IV	0.169	0.653	.029	3	view →
DLBC	OS	Median	All	0.613	0.945	.049	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: ZBTB40 tumor-vs-normal RNA expression · all ZBTB40 data types