ZBTB4

Across TCGA patient cohorts, ZBTB4 mutation is significantly associated with the RNA expression of many other genes, with 2,656 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZBTB4-associated genes across cancer lineages are OXSM, FXN, and MRPL16. Each is linked with ZBTB4 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZBTB4-to-partner and partner-to-ZBTB4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OXSM grouped by ZBTB4-low versus ZBTB4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZBTB4→partner) and Y-score (partner→ZBTB4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	OXSM →	+0.307	+1.938	<.001	.001	3	3
UCEC	FXN →	+0.385	+2.280	<.001	<.001	3	3
UCEC	MRPL16 →	+0.284	+1.781	<.001	.001	3	3
UCEC	MRM3 →	+0.427	+1.502	<.001	<.001	3	3
UCEC	TYMS →	+0.586	+1.638	.001	.009	3	3
UCEC	TIMM22 →	+0.400	+1.513	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,656 associations by consensus.

OXSM by ZBTB4 expression — UCEC

Explore this box plot interactively →