ZBTB4

Across TCGA patient cohorts, ZBTB4 mutation is significantly associated with the total protein of many other genes, with 41 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZBTB4-associated genes across cancer lineages are MEK1, mTOR_pS2448, and PDCD4. Each is linked with ZBTB4 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZBTB4-to-partner and partner-to-ZBTB4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by ZBTB4-low versus ZBTB4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZBTB4→partner) and Y-score (partner→ZBTB4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.304	+1.536	.003	.002	3	2
UCEC	mTOR_pS2448 →	-0.084	-1.228	.049	.041	3	2
UCEC	PDCD4 →	-0.307	-1.440	.023	.020	3	2
UCEC	ARID1A →	-0.106	-0.992	.043	.041	3	2
UCEC	ATM →	-0.333	-0.999	.010	.042	3	2
UCEC	4E-BP1_pT37_T46 →	-0.345	-2.489	.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

MEK1 by ZBTB4 expression — UCEC

Explore this box plot interactively →