ZBTB38

Across TCGA patient cohorts, ZBTB38 mutation is significantly associated with the total protein of many other genes, with 46 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZBTB38-associated genes across cancer lineages are eIF4E, ATM, and eEF2. Each is linked with ZBTB38 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZBTB38-to-partner and partner-to-ZBTB38 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by ZBTB38-low versus ZBTB38-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZBTB38→partner) and Y-score (partner→ZBTB38) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.145	+2.598	.016	.005	3	3
UCEC	ATM →	-0.426	-2.156	.001	.002	3	3
UCEC	eEF2 →	+0.249	+1.678	.015	.019	3	2
UCEC	ERK2 →	+0.196	+2.584	<.001	<.001	3	2
UCEC	Annexin-1 →	+0.502	+1.867	<.001	.004	3	2
UCEC	VHL →	-0.763	-1.415	<.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 46 associations by consensus.

eIF4E by ZBTB38 expression — UCEC

Explore this box plot interactively →