ZBTB38

Across TCGA cell cohorts, ZBTB38 mutation is significantly associated with the RNA expression of many other genes, with 37 significant associations in total. CNS shows the largest number of these associations.

The most reproducible ZBTB38-associated genes across cancer lineages are PF4, IFNA8, and ADGRE3. Each is linked with ZBTB38 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZBTB38-to-partner and partner-to-ZBTB38 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PF4 grouped by ZBTB38-low versus ZBTB38-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZBTB38→partner) and Y-score (partner→ZBTB38) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	PF4 →	+0.392	+3.453	<.001	.009	3	2
SOFT_TISSUE	IFNA8 →	+0.038	+4.930	<.001	.008	3	1
SOFT_TISSUE	ADGRE3 →	+0.006	+5.977	<.001	.001	3	1
SOFT_TISSUE	KRT6C →	+0.013	+4.930	<.001	.008	3	1
SOFT_TISSUE	PGK2 →	+0.209	+4.930	<.001	.008	3	1
SOFT_TISSUE	GSTA5 →	+0.025	+4.930	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

PF4 by ZBTB38 expression — SKIN

Explore this box plot interactively →