ZBTB33

Across TCGA pan-cancer cohorts, ZBTB33 mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of ZBTB33’s most consistent transcriptional readouts.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where ZBTB33 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types ZBTB33 is over-expressed in tumor, although a few such as PDAC show the opposite, repressed pattern.

PDAC, LSCC, and LUAD are the cancer types where ZBTB33 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ZBTB33 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
PDAC	Male	All	−0.581	<.001	8	view →
LSCC	All	III,IV	+0.483	<.001	8	view →
LUAD	All	II,III,IV	+0.158	.012	4	view →
OV	All	All	+0.465	.009	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

ZBTB33–PDAC

Open the PDAC breakdown →