ZBTB33

Across TCGA patient cohorts, ZBTB33 mutation is significantly associated with the total protein of many other genes, with 50 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZBTB33-associated genes across cancer lineages are Cyclin-B1, FOXO3a_pS318_S321, and ACVRL1. Each is linked with ZBTB33 in more than 3 cancer types. Because this analysis shows association rather than direction, both ZBTB33-to-partner and partner-to-ZBTB33 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by ZBTB33-low versus ZBTB33-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZBTB33→partner) and Y-score (partner→ZBTB33) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-B1 →	+0.679	+1.847	<.001	<.001	3	4
UCEC	FOXO3a_pS318_S321 →	-0.089	-1.405	.007	.008	3	2
UCEC	ACVRL1 →	-0.088	-1.243	.015	.016	3	2
UCEC	Rad50 →	-0.146	-1.349	.023	.031	3	2
UCEC	Annexin-1 →	+0.540	+1.502	<.001	<.001	3	2
UCEC	TFRC →	+0.562	+2.736	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 50 associations by consensus.

Cyclin-B1 by ZBTB33 expression — UCEC

Explore this box plot interactively →