ZBTB32

Across TCGA patient cohorts, ZBTB32 mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZBTB32-associated genes across cancer lineages are EGFR_pY1068, Ku80, and Caspase-8. Each is linked with ZBTB32 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZBTB32-to-partner and partner-to-ZBTB32 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by ZBTB32-low versus ZBTB32-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZBTB32→partner) and Y-score (partner→ZBTB32) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.392	-3.169	.004	.020	3	1
UCEC	Ku80 →	+0.279	+2.817	.031	.036	3	1
UCEC	Caspase-8 →	-0.333	-3.000	.015	.036	2	1
UCEC	INPP4B →	-0.404	-3.156	.022	.020	1	1
UCEC	p62 Lck ligand →	+0.526	+3.169	.003	.020	1	1
UCEC	Cyclin-B1 →	+0.749	+3.169	.015	.020	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

EGFR_pY1068 by ZBTB32 expression — UCEC

Explore this box plot interactively →