ZBTB21

Across TCGA patient cohorts, ZBTB21 protein abundance is significantly associated with the RNA expression of many other genes, with 3,801 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible ZBTB21-associated genes across cancer lineages are WDR4, RRP1, and FAM207A. Each is linked with ZBTB21 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZBTB21-to-partner and partner-to-ZBTB21 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ZBTB21 versus WDR4 in LSCC, with a Pearson correlation of 0.34.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZBTB21→partner) and Y-score (partner→ZBTB21) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	WDR4 →	+0.504	+0.249	<.001	.001	3	3
BRCA	RRP1 →	+0.598	+0.205	.001	.006	3	3
BRCA	FAM207A →	+0.866	+0.258	<.001	.006	3	3
HNSC	GAB1 →	-0.587	-0.395	<.001	<.001	3	2
HNSC	CYP20A1 →	-0.424	-0.331	<.001	.003	3	2
PDAC	VPS13C →	-0.320	-0.528	.002	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,801 associations by consensus.

ZBTB21 vs WDR4 — LSCC

Explore this scatter interactively →