ZBTB21

Across TCGA patient cohorts, ZBTB21 mutation is significantly associated with the RNA expression of many other genes, with 3,870 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZBTB21-associated genes across cancer lineages are MRPL50, NDC80, and SFXN1. Each is linked with ZBTB21 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZBTB21-to-partner and partner-to-ZBTB21 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MRPL50 grouped by ZBTB21-low versus ZBTB21-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZBTB21→partner) and Y-score (partner→ZBTB21) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MRPL50 →	+0.396	+2.694	.001	<.001	3	3
COAD	NDC80 →	+0.622	+3.362	.008	.005	3	3
UCEC	SFXN1 →	+0.604	+2.632	<.001	<.001	3	3
UCEC	MRPL22 →	+0.293	+3.457	<.001	<.001	3	3
SKCM	WBP1LP2 →	+0.662	+3.350	.001	.005	3	2
SKCM	RNA5SP34 →	+0.145	+4.488	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,870 associations by consensus.

MRPL50 by ZBTB21 expression — UCEC

Explore this box plot interactively →