ZBTB21

Across TCGA cell cohorts, ZBTB21 mutation is significantly associated with the RNA expression of many other genes, with 51 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ZBTB21-associated genes across cancer lineages are RTL4, REG3G, and IDI2. Each is linked with ZBTB21 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZBTB21-to-partner and partner-to-ZBTB21 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RTL4 grouped by ZBTB21-low versus ZBTB21-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZBTB21→partner) and Y-score (partner→ZBTB21) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	RTL4 →	+0.014	+2.982	.004	.007	3	2
BLOOD_Myeloma	REG3G →	+0.045	+3.906	.001	.009	3	1
BLOOD_Myeloma	IDI2 →	+0.029	+3.906	.001	.009	3	1
BLOOD_Myeloma	GRM5 →	+0.135	+3.906	.006	.009	3	1
BLOOD_Myeloma	DIPK1C →	+0.015	+3.906	.004	.009	3	1
BLOOD_Myeloma	PRR23A →	+0.060	+4.285	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 51 associations by consensus.

RTL4 by ZBTB21 expression — BLOOD_Leukemia

Explore this box plot interactively →