ZBTB20

Across TCGA pan-cancer cohorts, ZBTB20 mass-spec protein is linked to patient survival in 8 of 34 cancer types, making it a survival-associated ZBTB20 data layer compared with 27 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher ZBTB20 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated ZBTB20 expression acts as an unfavorable survival marker, although some lineages such as HNSC and CCRCC show a favorable association.

UCEC, HNSC, and PDAC are the cancer types where ZBTB20 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Tertile	II,III,IV	0.484	1.000	.012	16	view →
HNSC	DFS	Quartile	IV	0.807	0.518	.006	14	view →
PDAC	OS	Median	III,IV	0.300	0.563	.025	5	view →
GBM	DFS	Tertile	All	0.582	0.874	.016	5	view →
OV	DFS	Median	All	0.577	1.000	.026	4	view →
LSCC	DFS	Tertile	II,III,IV	0.808	1.000	.010	4	view →
CCRCC	DFS	Tertile	III,IV	0.838	0.543	.033	3	view →
LUAD	OS	Tertile	All	0.924	0.765	.033	2	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

ZBTB20–UCEC (OS)

Open the UCEC breakdown →