ZBTB20

Across TCGA patient cohorts, ZBTB20 mutation is significantly associated with the total protein of many other genes, with 50 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZBTB20-associated genes across cancer lineages are Beclin, Gab2, and EGFR_pY1068. Each is linked with ZBTB20 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZBTB20-to-partner and partner-to-ZBTB20 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Beclin grouped by ZBTB20-low versus ZBTB20-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZBTB20→partner) and Y-score (partner→ZBTB20) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	Beclin →	+0.144	+2.197	.027	.033	3	3
LUSC	Gab2 →	+0.565	+3.000	.002	.033	3	2
UCEC	EGFR_pY1068 →	-0.259	-2.584	.002	.001	3	2
UCEC	ERK2 →	+0.189	+2.700	.003	.005	3	2
UCEC	mTOR_pS2448 →	-0.109	-1.886	.028	.015	3	2
UCEC	Notch1 →	+0.143	+2.128	.002	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 50 associations by consensus.

Beclin by ZBTB20 expression — LUSC

Explore this box plot interactively →