ZBTB2

Across TCGA patient cohorts, ZBTB2 mutation is significantly associated with the RNA expression of many other genes, with 1,240 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZBTB2-associated genes across cancer lineages are ARPP19P1, RNU6-280P, and RNA5SP166. Each is linked with ZBTB2 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZBTB2-to-partner and partner-to-ZBTB2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ARPP19P1 grouped by ZBTB2-low versus ZBTB2-high in PRAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZBTB2→partner) and Y-score (partner→ZBTB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PRAD	ARPP19P1 →	+0.139	+5.053	<.001	.009	3	3
BRCA	RNU6-280P →	+0.182	+7.471	<.001	.008	3	2
HNSC	RNA5SP166 →	+0.298	+7.954	<.001	.008	3	2
COAD	RPL23AP69 →	+0.205	+3.738	.003	.006	3	2
BLCA	OR9G4 →	+0.039	+5.455	.001	.001	3	2
UCEC	ELOCP30 →	+0.064	+2.545	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,240 associations by consensus.

ARPP19P1 by ZBTB2 expression — PRAD

Explore this box plot interactively →