ZBTB2

Across TCGA patient cohorts, ZBTB2 mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZBTB2-associated genes across cancer lineages are Caspase-7-cleavedD198, EGFR_pY1068, and eIF4E. Each is linked with ZBTB2 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZBTB2-to-partner and partner-to-ZBTB2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by ZBTB2-low versus ZBTB2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZBTB2→partner) and Y-score (partner→ZBTB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.902	+2.459	<.001	.018	3	3
UCEC	EGFR_pY1068 →	-0.324	-3.807	<.001	<.001	3	2
UCEC	eIF4E →	+0.165	+3.169	.047	.019	2	3
UCEC	ERK2 →	+0.240	+2.700	.001	.006	3	2
UCEC	NF2 →	+0.277	+2.700	.001	.006	3	2
UCEC	p62 Lck ligand →	+0.271	+2.502	.033	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

Caspase-7-cleavedD198 by ZBTB2 expression — UCEC

Explore this box plot interactively →