ZBTB2

Across TCGA cell cohorts, ZBTB2 mutation is significantly associated with the RNA expression of many other genes, with 19 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible ZBTB2-associated genes across cancer lineages are HTN1, SSX7, and CFHR2. Each is linked with ZBTB2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZBTB2-to-partner and partner-to-ZBTB2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HTN1 grouped by ZBTB2-low versus ZBTB2-high in URINARY_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZBTB2→partner) and Y-score (partner→ZBTB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	HTN1 →	+0.197	+5.044	<.001	<.001	3	2
STOMACH	SSX7 →	+0.325	+4.285	<.001	.007	3	2
LARGE_INTESTINE	CFHR2 →	+0.038	+4.022	<.001	.006	3	2
URINARY_TRACT	C16orf90 →	+0.017	+4.087	<.001	.009	3	1
URINARY_TRACT	PCDH11Y →	+0.012	+4.087	<.001	.009	3	1
SKIN	C7orf77 →	+0.111	+4.415	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

HTN1 by ZBTB2 expression — URINARY_TRACT

Explore this box plot interactively →