ZBTB18

Across TCGA patient cohorts, ZBTB18 mutation is significantly associated with the total protein of many other genes, with 52 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZBTB18-associated genes across cancer lineages are ATM, c-Myc, and 4E-BP1. Each is linked with ZBTB18 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZBTB18-to-partner and partner-to-ZBTB18 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by ZBTB18-low versus ZBTB18-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZBTB18→partner) and Y-score (partner→ZBTB18) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.714	-2.169	<.001	.003	3	2
COAD	c-Myc →	-0.245	-3.161	.035	.019	3	2
UCEC	4E-BP1 →	+0.330	+3.321	.001	.009	3	2
UCEC	eEF2 →	+0.369	+2.115	.005	.016	3	2
UCEC	eIF4E →	+0.211	+2.222	.007	.010	3	2
UCEC	mTOR_pS2448 →	-0.162	-3.680	.003	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 52 associations by consensus.

ATM by ZBTB18 expression — UCEC

Explore this box plot interactively →