ZBTB18

Across TCGA cell cohorts, ZBTB18 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,973 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ZBTB18-associated GO terms across cancer lineages are Regulation of alternative mRNA splicing, via spliceosome, Negative regulation of chromosome organization, and Modulation of microtubule cytoskeleton involved in cerebral cortex radial glia guided migration. Each is linked with ZBTB18 in more than 9 cancer types. Because this analysis shows association rather than direction, both ZBTB18-to-partner and partner-to-ZBTB18 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of alternative mRNA splicing, via spliceosome grouped by ZBTB18-low versus ZBTB18-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ZBTB18→partner) and Y-score (partner→ZBTB18) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Regulation of alternative mRNA splicing, via spliceosome →	+0.107	+1.400	.002	.002	3	10
UPPER_AERODIGESTIVE_TRACT	Negative regulation of chromosome organization →	+0.085	+1.095	<.001	<.001	3	9
SKIN	Modulation of microtubule cytoskeleton involved in cerebral cortex radial glia guided migration →	+0.155	+1.094	<.001	<.001	3	9
UPPER_AERODIGESTIVE_TRACT	mRNA transport →	+0.114	+1.332	.001	<.001	3	9
LIVER	Nucleus organization →	+0.069	+1.863	<.001	<.001	3	9
UPPER_AERODIGESTIVE_TRACT	DNA biosynthetic process →	+0.085	+1.169	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,973 associations by consensus.

Regulation of alternative mRNA splicing, via spliceosome by ZBTB18 expression — OESOPHAGUS

Explore this box plot interactively →