ZBTB18

Across TCGA cell cohorts, ZBTB18 mutation is significantly associated with the RNA expression of many other genes, with 10 significant associations in total. OVARY shows the largest number of these associations.

The most reproducible ZBTB18-associated genes across cancer lineages are PNPLA5, OR4F5, and USP29. Each is linked with ZBTB18 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZBTB18-to-partner and partner-to-ZBTB18 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PNPLA5 grouped by ZBTB18-low versus ZBTB18-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZBTB18→partner) and Y-score (partner→ZBTB18) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PNPLA5 →	+0.432	+4.467	<.001	.004	3	1
LARGE_INTESTINE	OR4F5 →	+0.042	+4.930	<.001	.001	3	1
LUNG_NSCLC_LUAD	USP29 →	+0.012	+4.662	<.001	.005	3	1
LUNG_NSCLC_LUAD	CCDC105 →	+0.004	+4.662	<.001	.005	3	1
LUNG_NSCLC_LUAD	PRAMEF6 →	+0.051	+4.947	<.001	.001	3	1
BLOOD_Lymphoma	AVP →	+0.031	+5.209	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

PNPLA5 by ZBTB18 expression — LARGE_INTESTINE

Explore this box plot interactively →