ZBTB17

Across TCGA patient cohorts, ZBTB17 mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZBTB17-associated genes across cancer lineages are eIF4E, ERK2, and Fibronectin. Each is linked with ZBTB17 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZBTB17-to-partner and partner-to-ZBTB17 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by ZBTB17-low versus ZBTB17-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZBTB17→partner) and Y-score (partner→ZBTB17) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.156	+1.925	.039	.005	3	1
UCEC	ERK2 →	+0.185	+2.321	.007	.005	3	1
UCEC	Fibronectin →	-0.293	-1.990	.013	.030	3	1
UCEC	ACC1 →	+0.316	+1.584	.015	.019	3	1
UCEC	Lck →	+0.284	+2.459	<.001	.018	3	1
UCEC	MEK1 →	+0.297	+2.115	.024	.017	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

eIF4E by ZBTB17 expression — UCEC

Explore this box plot interactively →