ZBTB17

Across TCGA cell cohorts, ZBTB17 mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible ZBTB17-associated genes across cancer lineages are PRAMEF33, RBPJL, and PDE6H. Each is linked with ZBTB17 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZBTB17-to-partner and partner-to-ZBTB17 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRAMEF33 grouped by ZBTB17-low versus ZBTB17-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZBTB17→partner) and Y-score (partner→ZBTB17) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	PRAMEF33 →	+0.023	+5.415	<.001	.004	3	1
LUNG_SCLC	RBPJL →	+0.215	+3.946	.001	.002	3	1
LUNG_SCLC	PDE6H →	+1.145	+3.906	.002	.002	3	1
LUNG_SCLC	TPRX1 →	+0.021	+3.684	.007	.001	3	1
LUNG_SCLC	AGTR2 →	+0.015	+3.256	.008	.005	3	1
LUNG_SCLC	PPIAL4F →	+0.091	+3.256	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

PRAMEF33 by ZBTB17 expression — SKIN

Explore this box plot interactively →