ZBTB16

Across TCGA cell cohorts, ZBTB16 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,728 significant associations in total. BONE shows the largest number of these associations.

The most reproducible ZBTB16-associated GO terms across cancer lineages are Regulation of cytoplasmic translational initiation, Positive regulation of lysosomal protein catabolic process, and Regulation of monoatomic cation transmembrane transport. Each is linked with ZBTB16 in more than 4 cancer types. Because this analysis shows association rather than direction, both ZBTB16-to-partner and partner-to-ZBTB16 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of cytoplasmic translational initiation grouped by ZBTB16-low versus ZBTB16-high in BLOOD_Leukemia.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ZBTB16→partner) and Y-score (partner→ZBTB16) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	Regulation of cytoplasmic translational initiation →	+0.080	+1.350	<.001	.005	3	5
BONE	Positive regulation of lysosomal protein catabolic process →	+0.170	+1.160	<.001	.006	3	5
BONE	Regulation of monoatomic cation transmembrane transport →	-0.076	-1.193	<.001	.001	3	5
BONE	Dolichyl monophosphate biosynthetic process →	+0.121	+1.378	<.001	.006	3	5
BONE	Positive regulation of respiratory gaseous exchange →	+1.807	+1.644	<.001	<.001	3	4
LUNG_SCLC	Negative regulation of chromatin organization →	+0.159	+1.003	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,728 associations by consensus.

Regulation of cytoplasmic translational initiation by ZBTB16 expression — BLOOD_Leukemia

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