Across TCGA pan-cancer cohorts, ZBTB12 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated ZBTB12 data layer compared with 28 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher ZBTB12 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated ZBTB12 expression acts as an unfavorable survival marker, although some lineages such as PDAC show a favorable association.

UCEC, LSCC, and PDAC are the cancer types where ZBTB12 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Quartile	All	0.539	1.000	.010	14	view →
LSCC	OS	Median	All	0.933	1.000	.020	8	view →
PDAC	OS	Median	All	0.696	0.226	.020	4	view →
GBM	DFS	Quartile	All	0.159	0.382	.032	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: ZBTB12 tumor-vs-normal RNA expression · all ZBTB12 data types