ZBP1

Across TCGA pan-cancer cohorts, ZBP1 mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of ZBP1’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where ZBP1 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types ZBP1 is over-expressed in tumor, although a few such as CCRCC show the opposite, repressed pattern.

LUAD, LSCC, and HNSC are the cancer types where ZBP1 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ZBP1 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Male	All	+0.231	<.001	6	view →
LSCC	Female	All	+0.355	.010	2	view →
HNSC	All	All	+0.178	.039	2	view →
CCRCC	Male	All	−1.420	.029	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

ZBP1–LUAD

Open the LUAD breakdown →