Across TCGA pan-cancer cohorts, ZBED8 Mutation is linked to patient survival in 2 of 34 cancer types, making it a survival-associated ZBED8 data layer compared with 22 for mass-spec protein and 7 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher ZBED8 Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated ZBED8 expression acts as an unfavorable survival marker, although some lineages such as UCEC and SKCM show a favorable association.

UCEC and SKCM are the cancer types where ZBED8 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	II,III,IV	1.000	0.438	.013	28	view →
SKCM	DFS	Median	II,III,IV	1.000	0.561	.043	1	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

Exploration

Same gene, other analysis: ZBED8 tumor-vs-normal RNA expression · all ZBED8 data types