Across TCGA patient cohorts, ZBED8 mutation is significantly associated with the total protein of many other genes, with 29 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZBED8-associated genes across cancer lineages are EGFR_pY1068, A-Raf_pS299, and ERK2. Each is linked with ZBED8 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZBED8-to-partner and partner-to-ZBED8 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZBED8→partner) and Y-score (partner→ZBED8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.200	-2.222	.026	.010	3	1
UCEC	A-Raf_pS299 →	-0.085	-2.700	.047	.006	3	1
UCEC	ERK2 →	+0.174	+3.321	.011	.009	3	1
UCEC	ACC_pS79 →	+0.353	+2.115	.004	.016	3	1
UCEC	ACC1 →	+0.374	+2.321	.004	.001	3	1
UCEC	Ku80 →	+0.204	+2.125	.016	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

Exploration

ZBED8 survival (RNA) · tumor vs normal (RNA) · all ZBED8 data types