ZBED4

Across TCGA patient cohorts, ZBED4 mutation is significantly associated with the RNA expression of many other genes, with 4,561 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZBED4-associated genes across cancer lineages are RPL23AP82, PPP1R9A-AS1, and NAE1. Each is linked with ZBED4 in more than 3 cancer types. Because this analysis shows association rather than direction, both ZBED4-to-partner and partner-to-ZBED4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RPL23AP82 grouped by ZBED4-low versus ZBED4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZBED4→partner) and Y-score (partner→ZBED4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RPL23AP82 →	+0.380	+1.496	<.001	<.001	3	3
UCEC	PPP1R9A-AS1 →	+0.091	+1.362	.009	<.001	3	3
UCEC	NAE1 →	+0.421	+1.485	<.001	<.001	3	3
COAD	PBK →	+0.809	+2.625	.003	.005	3	3
UCEC	LEPROTL1 →	+0.344	+3.354	<.001	<.001	3	3
UCEC	MED31 →	+0.420	+2.096	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,561 associations by consensus.

RPL23AP82 by ZBED4 expression — UCEC

Explore this box plot interactively →