ZBED4

Across TCGA patient cohorts, ZBED4 mutation is significantly associated with the total protein of many other genes, with 57 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZBED4-associated genes across cancer lineages are Akt, ATM, and Rab25. Each is linked with ZBED4 in more than 4 cancer types. Because this analysis shows association rather than direction, both ZBED4-to-partner and partner-to-ZBED4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Akt grouped by ZBED4-low versus ZBED4-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZBED4→partner) and Y-score (partner→ZBED4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Akt →	-0.783	-3.000	<.001	.035	3	4
COAD	ATM →	-0.761	-3.313	<.001	.010	2	5
UCEC	Rab25 →	-0.205	-1.000	.018	.020	3	3
UCEC	Shc_pY317 →	-0.146	-1.584	<.001	<.001	3	3
UCEC	TFRC →	+0.434	+2.584	.001	<.001	3	3
COAD	eIF4E →	+0.199	+2.820	.017	.035	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 57 associations by consensus.

Akt by ZBED4 expression — COAD

Explore this box plot interactively →