ZBED4

Across TCGA cell cohorts, ZBED4 mutation is significantly associated with the RNA expression of many other genes, with 1,100 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ZBED4-associated genes across cancer lineages are TMEM213, SULT1C3, and CBY1. Each is linked with ZBED4 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZBED4-to-partner and partner-to-ZBED4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TMEM213 grouped by ZBED4-low versus ZBED4-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZBED4→partner) and Y-score (partner→ZBED4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	TMEM213 →	+0.061	+2.906	<.001	.004	3	3
LUNG_NSCLC_LUAD	SULT1C3 →	+0.053	+3.362	<.001	.007	3	2
LARGE_INTESTINE	CBY1 →	+0.576	+3.619	<.001	<.001	3	2
LARGE_INTESTINE	JOSD1 →	+0.555	+3.321	<.001	.002	3	2
LARGE_INTESTINE	TRMU →	+0.583	+3.043	<.001	<.001	3	2
LARGE_INTESTINE	GNPNAT1 →	+0.526	+2.451	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,100 associations by consensus.

TMEM213 by ZBED4 expression — BLOOD_Leukemia

Explore this box plot interactively →