ZBED3

Across TCGA cell cohorts, ZBED3 mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ZBED3-associated genes across cancer lineages are SLCO1C1, TKTL2, and SLAMF8. Each is linked with ZBED3 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZBED3-to-partner and partner-to-ZBED3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SLCO1C1 grouped by ZBED3-low versus ZBED3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZBED3→partner) and Y-score (partner→ZBED3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SLCO1C1 →	+0.515	+3.035	<.001	.003	3	1
LARGE_INTESTINE	TKTL2 →	+0.034	+3.187	.004	.006	3	1
LARGE_INTESTINE	SLAMF8 →	+0.138	+4.132	<.001	<.001	3	1
LARGE_INTESTINE	MROH2A →	+0.417	+3.228	<.001	.009	3	1
LARGE_INTESTINE	PBOV1 →	+0.064	+3.555	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

SLCO1C1 by ZBED3 expression — LARGE_INTESTINE

Explore this box plot interactively →