ZBBX

Across TCGA pan-cancer cohorts, ZBBX Mutation is linked to patient survival in 11 of 34 cancer types, making it a survival-associated ZBBX data layer compared with 26 for mass-spec protein and 1 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher ZBBX Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated ZBBX expression acts as an unfavorable survival marker, although some lineages such as UCEC and LUAD show a favorable association.

KIRC, UCEC, and OV are the cancer types where ZBBX Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	All	0.126	0.631	<.001	42	view →
UCEC	DFS	Median	II,III,IV	0.941	0.298	.002	34	view →
OV	DFS	Median	All	0.136	0.542	<.001	18	view →
MESO	OS	Median	All	0.130	0.557	.019	18	view →
LIHC	OS	Median	All	0.122	0.707	<.001	15	view →
THCA	DFS	Median	II,III,IV	0.145	0.842	<.001	12	view →
BRCA	OS	Median	III,IV	0.157	0.906	<.001	12	view →
COAD	OS	Median	III,IV	0.163	0.791	.004	12	view →
LUAD	DFS	Median	II,III,IV	1.000	0.224	.018	7	view →
SARC	OS	Median	All	0.210	0.730	.022	3	view →
SKCM	OS	Median	III,IV	0.489	0.733	.025	3	view →

Pink = unfavorable, green = favorable. Showing the 11 strongest of 11 lineages.

ZBBX–KIRC (OS)

Open the KIRC breakdown →