Across TCGA patient cohorts, ZAR1L mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZAR1L-associated genes across cancer lineages are 14-3-3_beta, ERK2, and Fibronectin. Each is linked with ZAR1L in more than 1 cancer types. Because this analysis shows association rather than direction, both ZAR1L-to-partner and partner-to-ZAR1L results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZAR1L→partner) and Y-score (partner→ZAR1L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.109	-2.558	.003	.010	3	1
UCEC	ERK2 →	+0.214	+2.584	.003	.010	3	1
UCEC	Fibronectin →	-0.280	-1.797	.023	.025	3	1
UCEC	JNK_pT183_Y185 →	-0.179	-1.401	.004	.046	3	1
UCEC	JNK2 →	+0.251	+3.196	<.001	.009	3	1
UCEC	MEK1 →	+0.397	+2.700	.003	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

Exploration

ZAR1L survival (RNA) · tumor vs normal (RNA) · all ZAR1L data types