ZAR1

Across TCGA patient cohorts, ZAR1 mutation is significantly associated with the RNA expression of many other genes, with 35 significant associations in total. CESC shows the largest number of these associations.

The most reproducible ZAR1-associated genes across cancer lineages are RNU7-107P, SSTR5, and TRAJ30. Each is linked with ZAR1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZAR1-to-partner and partner-to-ZAR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU7-107P grouped by ZAR1-low versus ZAR1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZAR1→partner) and Y-score (partner→ZAR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RNU7-107P →	+0.577	+7.816	<.001	.008	3	1
UCEC	SSTR5 →	+1.050	+3.608	<.001	.009	3	1
CESC	TRAJ30 →	+0.529	+5.103	<.001	.008	3	1
CESC	RNU6-1109P →	+0.330	+5.669	<.001	.003	3	1
CESC	TXNL4AP1 →	+0.172	+5.539	<.001	.004	3	1
CESC	NUS1P4 →	+0.070	+5.010	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

RNU7-107P by ZAR1 expression — SKCM

Explore this box plot interactively →