ZADH2

Across TCGA cell cohorts, ZADH2 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,379 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible ZADH2-associated GO terms across cancer lineages are Host-mediated perturbation of viral transcription, Host-mediated activation of viral transcription, and Positive regulation of intracellular steroid hormone receptor signaling pathway. Each is linked with ZADH2 in more than 11 cancer types. Because this analysis shows association rather than direction, both ZADH2-to-partner and partner-to-ZADH2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Host-mediated perturbation of viral transcription grouped by ZADH2-low versus ZADH2-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ZADH2→partner) and Y-score (partner→ZADH2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Host-mediated perturbation of viral transcription →	+0.072	+0.735	<.001	.001	3	12
LUNG_NSCLC_LUSC	Host-mediated activation of viral transcription →	+0.119	+1.432	.007	.003	2	12
UPPER_AERODIGESTIVE_TRACT	Positive regulation of intracellular steroid hormone receptor signaling pathway →	+0.103	+0.613	.002	.002	3	10
LARGE_INTESTINE	Signal transduction by p53 class mediator →	+0.064	+0.895	<.001	<.001	3	9
LUNG_NSCLC_LUSC	Exit from mitosis →	+0.122	+1.137	<.001	.002	3	9
BREAST	Positive regulation of macrophage proliferation →	+0.199	+0.866	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,379 associations by consensus.

Host-mediated perturbation of viral transcription by ZADH2 expression — BREAST

Explore this box plot interactively →