Across TCGA patient cohorts, ZACN mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZACN-associated genes across cancer lineages are HER3_pY1289, ERK2, and JNK2. Each is linked with ZACN in more than 1 cancer types. Because this analysis shows association rather than direction, both ZACN-to-partner and partner-to-ZACN results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZACN→partner) and Y-score (partner→ZACN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	HER3_pY1289 →	+0.090	+2.348	.037	.019	3	2
UCEC	ERK2 →	+0.221	+2.999	.022	.035	3	1
UCEC	JNK2 →	+0.249	+3.179	.012	.010	3	1
UCEC	Ku80 →	+0.383	+3.179	.001	.010	3	1
UCEC	N-Cadherin →	+0.292	+2.817	.006	.036	3	1
UCEC	NDRG1_pT346 →	-0.597	-3.459	.015	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

Exploration

ZACN survival (RNA) · tumor vs normal (RNA) · all ZACN data types