Across TCGA patient cohorts, YY2 mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible YY2-associated genes across cancer lineages are Notch1, Rictor_pT1135, and 4E-BP1. Each is linked with YY2 in more than 2 cancer types. Because this analysis shows association rather than direction, both YY2-to-partner and partner-to-YY2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (YY2→partner) and Y-score (partner→YY2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.254	+3.000	<.001	.001	3	3
UCEC	Rictor_pT1135 →	-0.096	-2.321	.022	.034	3	2
UCEC	4E-BP1 →	+0.226	+3.199	.043	.009	3	2
UCEC	C-Raf →	+0.202	+1.807	<.001	.027	3	2
UCEC	EGFR_pY1068 →	-0.305	-1.807	.003	.027	3	1
UCEC	A-Raf_pS299 →	-0.163	-3.459	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

Exploration

YY2 survival (RNA) · tumor vs normal (RNA) · all YY2 data types