Across TCGA cell cohorts, YY2 mutation is significantly associated with the RNA expression of many other genes, with 11 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible YY2-associated genes across cancer lineages are DMRTC2, OR1L3, and ASB17. Each is linked with YY2 in more than 1 cancer types. Because this analysis shows association rather than direction, both YY2-to-partner and partner-to-YY2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (YY2→partner) and Y-score (partner→YY2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	DMRTC2 →	+0.013	+5.643	<.001	.002	3	1
SKIN	OR1L3 →	+0.022	+4.415	<.001	.007	3	1
OVARY	ASB17 →	+0.023	+5.807	<.001	.001	3	1
BLOOD_Leukemia	CYP7A1 →	+0.015	+4.285	<.001	.006	3	1
BLOOD_Leukemia	ACTBL2 →	+0.026	+3.551	<.001	.008	3	1
BLOOD_Leukemia	TEX13B →	+0.017	+3.475	.002	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

Exploration

YY2 survival (RNA) · tumor vs normal (RNA) · all YY2 data types