YY1AP1

Across TCGA pan-cancer cohorts, YY1AP1 Mutation is linked to patient survival in 11 of 34 cancer types, making it a survival-associated YY1AP1 data layer compared with 22 for mass-spec protein and 2 for mass-spec protein.

The strongest signal is observed in uterine carcinosarcoma (UCS), where higher YY1AP1 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated YY1AP1 expression acts as an unfavorable survival marker, although some lineages such as BLCA and SKCM show a favorable association.

UCS, BLCA, and KICH are the cancer types where YY1AP1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCS	DFS	Median	IV	0.132	0.718	.002	36	view →
BLCA	DFS	Median	All	1.000	0.329	.010	31	view →
KICH	DFS	Median	All	0.102	0.848	.004	13	view →
BRCA	OS	Median	All	0.410	0.924	.002	12	view →
SCLC	DFS	Median	II,III,IV	0.137	0.562	.013	9	view →
LIHC	DFS	Median	II,III,IV	0.097	0.429	.014	9	view →
SKCM	DFS	Median	II,III,IV	0.489	0.245	.018	7	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →
LUAD	DFS	Median	IV	0.342	0.893	<.001	6	view →
LUSC	DFS	Median	All	0.873	0.364	.016	4	view →
GBM	OS	Median	All	0.109	0.415	.032	3	view →

Pink = unfavorable, green = favorable. Showing the 11 strongest of 11 lineages.

YY1AP1–UCS (DFS)

Open the UCS breakdown →