YWHAZ

Across TCGA pan-cancer cohorts, YWHAZ mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated YWHAZ data layer compared with 25 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher YWHAZ mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated YWHAZ expression acts as an unfavorable survival marker, although some lineages such as HNSC and GBM show a favorable association.

CCRCC, LUAD, and HNSC are the cancer types where YWHAZ mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Tertile	All	0.575	0.872	.001	30	view →
LUAD	DFS	Tertile	All	0.548	0.844	.009	13	view →
HNSC	DFS	Median	All	0.994	0.909	.005	12	view →
PDAC	DFS	Median	IV	0.214	0.785	.006	9	view →
GBM	OS	Tertile	All	0.956	0.792	.027	4	view →
LSCC	DFS	Median	II,III,IV	0.963	0.871	.049	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

YWHAZ–CCRCC (DFS)

Open the CCRCC breakdown →