YWHAZ

Across TCGA patient cohorts, YWHAZ mutation is significantly associated with the total protein of many other genes, with 20 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible YWHAZ-associated genes across cancer lineages are Heregulin, JNK_pT183_Y185, and Notch1. Each is linked with YWHAZ in more than 1 cancer types. Because this analysis shows association rather than direction, both YWHAZ-to-partner and partner-to-YWHAZ results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Heregulin grouped by YWHAZ-low versus YWHAZ-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (YWHAZ→partner) and Y-score (partner→YWHAZ) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Heregulin →	-0.132	-2.459	.026	.020	3	1
UCEC	JNK_pT183_Y185 →	-0.225	-3.571	.005	.002	3	1
UCEC	Notch1 →	+0.158	+2.459	.020	.020	3	1
UCEC	p38-MAPK_pT180_Y182 →	-0.619	-3.000	.004	.036	3	1
UCEC	P-Cadherin →	-0.173	-2.999	.013	.035	3	1
UCEC	Rad50 →	-0.313	-3.584	.007	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

Heregulin by YWHAZ expression — UCEC

Explore this box plot interactively →