YWHAQP4

Across TCGA pan-cancer cohorts, YWHAQP4 RNA is linked to patient survival in 19 of 34 cancer types, making it the most broadly survival-associated YWHAQP4 data layer.

The strongest signal is observed in lymphoid neoplasm diffuse large b-cell lymphoma (DLBC), where higher YWHAQP4 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated YWHAQP4 expression acts as an unfavorable survival marker, although some lineages such as MESO and GBM show a favorable association.

DLBC, MESO, and THCA are the cancer types where YWHAQP4 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
DLBC	DFS	Tertile	II,III,IV	0.107	0.951	<.001	74	view →
MESO	OS	Tertile	All	0.659	0.202	.013	24	view →
THCA	OS	Quartile	IV	0.863	1.000	.010	18	view →
LUAD	DFS	Quartile	All	0.546	0.696	.019	16	view →
GBM	DFS	Tertile	All	0.391	0.155	.003	14	view →
PRAD	OS	Median	All	1.000	0.830	.010	14	view →
UCEC	OS	Tertile	All	0.891	0.963	.002	12	view →
UCS	OS	Tertile	IV	0.844	0.261	.031	12	view →
LGG	DFS	Quartile	All	0.670	0.852	.023	10	view →
READ	OS	Quartile	II,III,IV	0.758	1.000	.014	9	view →
ACC	OS	Quartile	All	0.221	0.659	.006	9	view →
CHOL	OS	Tertile	II,III,IV	1.000	0.412	.025	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

YWHAQP4–DLBC (DFS)

Open the DLBC breakdown →