YWHAQ

Across TCGA patient cohorts, YWHAQ mutation is significantly associated with the total protein of many other genes, with 26 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible YWHAQ-associated genes across cancer lineages are mTOR, p62 Lck ligand, and ACC_pS79. Each is linked with YWHAQ in more than 1 cancer types. Because this analysis shows association rather than direction, both YWHAQ-to-partner and partner-to-YWHAQ results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mTOR grouped by YWHAQ-low versus YWHAQ-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (YWHAQ→partner) and Y-score (partner→YWHAQ) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	mTOR →	+0.189	+2.459	.015	.020	3	2
UCEC	p62 Lck ligand →	+0.339	+2.817	.031	.036	3	2
UCEC	ACC_pS79 →	+0.413	+2.459	.013	.020	3	1
UCEC	Ku80 →	+0.224	+2.820	.049	.035	3	1
UCEC	Mre11 →	-0.139	-3.584	<.001	.002	3	1
UCEC	p27_pT157 →	-0.062	-2.420	.026	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

mTOR by YWHAQ expression — UCEC

Explore this box plot interactively →