YWHAQ

Across TCGA cell cohorts, YWHAQ RNA expression is significantly associated with the go_rna of many other GO terms, with 4,660 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible YWHAQ-associated GO terms across cancer lineages are Negative regulation of metaphase/anaphase transition of cell cycle, Negative regulation of chromosome separation, and Negative regulation of mitotic sister chromatid separation. Each is linked with YWHAQ in more than 15 cancer types. Because this analysis shows association rather than direction, both YWHAQ-to-partner and partner-to-YWHAQ results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of metaphase/anaphase transition of cell cycle grouped by YWHAQ-low versus YWHAQ-high in PANCREAS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (YWHAQ→partner) and Y-score (partner→YWHAQ) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	Negative regulation of metaphase/anaphase transition of cell cycle →	+0.134	+0.918	<.001	<.001	3	16
PANCREAS	Negative regulation of chromosome separation →	+0.134	+0.918	<.001	<.001	3	16
PANCREAS	Negative regulation of mitotic sister chromatid separation →	+0.151	+0.953	<.001	<.001	3	16
PANCREAS	Spindle checkpoint signaling →	+0.101	+0.698	<.001	<.001	3	16
PANCREAS	Negative regulation of sister chromatid segregation →	+0.151	+0.953	<.001	<.001	3	16
PANCREAS	Negative regulation of mitotic sister chromatid segregation →	+0.151	+0.953	<.001	<.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,660 associations by consensus.

Negative regulation of metaphase/anaphase transition of cell cycle by YWHAQ expression — PANCREAS

Explore this box plot interactively →