YWHAH

Across TCGA pan-cancer cohorts, YWHAH mass-spec protein differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of YWHAH’s most consistent transcriptional readouts.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where YWHAH mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types YWHAH is over-expressed in tumor, although a few such as COAD and LSCC show the opposite, repressed pattern.

CCRCC, HNSC, and PDAC are the cancer types where YWHAH tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in YWHAH mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
CCRCC	Female	II,III,IV	+0.714	<.001	12	view →
HNSC	Male	IV	+0.462	<.001	11	view →
PDAC	Male	All	+0.601	<.001	7	view →
COAD	All	All	−0.096	<.001	7	view →
LSCC	Female	All	−0.217	<.001	6	view →
OV	All	All	+0.241	.028	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

YWHAH–CCRCC

Open the CCRCC breakdown →