YWHAH

Across TCGA patient cohorts, YWHAH mutation is significantly associated with the RNA expression of many other genes, with 2,408 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible YWHAH-associated genes across cancer lineages are RNU6-271P, RNA5SP113, and RNA5SP287. Each is linked with YWHAH in more than 1 cancer types. Because this analysis shows association rather than direction, both YWHAH-to-partner and partner-to-YWHAH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-271P grouped by YWHAH-low versus YWHAH-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (YWHAH→partner) and Y-score (partner→YWHAH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNU6-271P →	+0.232	+2.977	<.001	.009	3	2
UCEC	RNA5SP113 →	+0.451	+3.351	<.001	.004	3	2
UCEC	RNA5SP287 →	+0.277	+3.249	<.001	.005	3	2
SKCM	RNU6-839P →	+0.458	+7.816	<.001	.008	3	1
SKCM	RNU6-1075P →	+0.458	+7.816	<.001	.008	3	1
SKCM	RNU6-643P →	+0.312	+7.816	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,408 associations by consensus.

RNU6-271P by YWHAH expression — UCEC

Explore this box plot interactively →