YWHAG

Across TCGA cell cohorts, YWHAG mutation is significantly associated with the mutation status of many other genes, with 2,330 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible YWHAG-associated genes across cancer lineages are SYT7, MYNN, and C1QTNF4. Each is linked with YWHAG in more than 3 cancer types. Because this analysis shows association rather than direction, both YWHAG-to-partner and partner-to-YWHAG results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SYT7 grouped by YWHAG-low versus YWHAG-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (YWHAG→partner) and Y-score (partner→YWHAG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SYT7 →	+3.744	+4.044	.003	.003	1	4
LARGE_INTESTINE	MYNN →	+3.329	+3.799	.005	.005	1	3
LARGE_INTESTINE	C1QTNF4 →	+3.329	+3.799	.005	.005	1	3
LARGE_INTESTINE	VWC2L →	+4.329	+4.329	.001	.001	1	3
LARGE_INTESTINE	LIN9 →	+3.744	+4.044	.003	.003	1	3
LARGE_INTESTINE	DCAF12 →	+5.329	+4.672	<.001	<.001	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,330 associations by consensus.

SYT7 by YWHAG expression — LARGE_INTESTINE

Explore this box plot interactively →